What Are the Active Ingredients in Modafinil?

What is Modafinil Made Of?
October 23, 2017
Is Modafinil a Stimulant?
October 23, 2017
What Are the Active Ingredients in Modafinil?

What Are the Active Ingredients in Modafinil?

What are the active ingredients in Modafinil? Well, there is only one active ingredient in this drug and that is modafinil. It also has some inactive ingredients including povidone, lactose monohydrate, magnesium stearate, pregelatinized starch, croscarmellose sodium, lactose monohydrate and microcrystalline cellulose.

Modafinil – A Wake-Promoting Agent

Modafinil is the first and so far the only one in its category of wake-promoting agents. It is the only FDA-approved prescription medicine for treatment of extreme daytime sleeping related to narcolepsy, hypersomnia and excessive sleepiness related to SWSD and OSAHS.

Modafinil is also known by other names including Provigil, Nuvigil, Alertec, Modavigil, and Vigicer. Compared to other stimulants targeting the central nervous system, Modafinil is different in structure.

In truth, the mechanism as to how it works is still unknown. The only thing that researchers can be sure is that it works differently catecholaminergic-enhancing and dopaminergic stimulant medications. Today, the drug is classified as “Guanfacine extended release (GXR) dopamine reuptake inhibitor”.

Two Main the Metabolites of Modafinil

The two main metabolites of Modafinil is modafinil acid and modafinil sulfone. Modafinil acid is the chief metabolite and similar to modafinil sulfone, it is inactive and does not appear to have any contribution in Modafinil’s effect as a stimulant or how it helps improve wakefulness.

Inactive Ingredients of Modafinil

  • Povidone
  • Lactose monohydrate
  • Magnesium stearate
  • Pregelatinized Starch
  • Croscarmellose sodium
  • Lactose monohydrate
  • Microcrystalline cellulose

These inactive ingredients mainly help to form and bind the tablet. They do not have any effect on the wakefulness of the drug or its stimulant effects.

How to Use Modafinil

How do you use modafinil to improve your wakefulness? First, it is important that you read the medication guide given to you by the pharmacist before you start using this drug. If there are ever things you are confused about, do not hesitate to ask your pharmacist or doctor.

Using Modafinil for Obstructive Sleep Apnoea

In using the drug for treating obstructive sleep apnoea, you should take it by mouth, with or without any food. Take the medication as instructed by your doctor, which is often once every day in the morning. T

Using Modafinil for Narcolepsy

In treating narcolepsy, the medication is usually taken by mouth, also with or without food and as instructed by your doctor. It usually is taken only once every day in the morning. Sometimes, if the doctor instructs you to, you can divide your modafinil dose morning and noon.

Using Modafinil for Shift Work Sleep Syndrome

In using the medication for shift work sleep syndrome, you should take it once every day about an hour before starting your shift for work. Just like in narcolepsy and obstructive sleep apnoea, you should take modafinil orally, either with food or not, or as directed by your doctor.

Modafinil is a prescription drug and with that, you need to first get checked up before you can take it. Make sure that the first time and each time you get a refill of Modafinil you read the medication guide to remind yourself how it works and what side effects it may have.

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